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TB-500 works systemically it sequesters actin to enable cell migration, dials down NF-kB inflammatory signaling, and promotes blood vessel growth through its own VEGF pathways

removal of potential oxidants that may be contributing to hemolysis, and treatment of associated infections

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23 Patients with small patches of plaques may be hard to treat with systemic therapy alone but can be treated successfully when FAE is combined with another therapy such as phototherapy, topical, or other systemic drugs